M21. Social Reward Learning Deficits in Patients With Schizophrenia

Cigarette smoking reduces medication- associated deficits in reward processing in patients with schizophrenia

Inferring reward prediction errors in patients with schizophrenia: a dynamic reward task for reinforcement learning

Abnormalities in the dopamine system have long been implicated in explanations of reinforcement learning and psychosis. The updated reward prediction error (RPE)-a discrepancy between the predicted and actual rewards-is thought to be encoded by dopaminergic neurons. Dysregulation of dopamine systems could alter the appraisal of stimuli and eventually lead to schizophrenia. Accordingly, the meas...

The Role of Social Cognition in Predicting the Social Functioning in Patients With Chronic Schizophrenia

Objectives: Patients with schizophrenia are characterized with deficiencies in various aspects of social functioning. Given the relationship between social functioning deficits and relapse in these patients, identification of underlying factors is of significant importance. Thus, in this study, the contribution of each dimension of social cognition (Emotion Perception [EP], Theory of Mind [ToM]...

Reduced reward-related probability learning in schizophrenia patients

Although it is known that individuals with schizophrenia demonstrate marked impairment in reinforcement learning, the details of this impairment are not known. The aim of this study was to test the hypothesis that reward-related probability learning is altered in schizophrenia patients. Twenty-five clinically stable schizophrenia patients and 25 age- and gender-matched controls participated in ...

Altered cingulo-striatal function underlies reward drive deficits in schizophrenia.

Amotivation in schizophrenia is assumed to involve dysfunctional dopaminergic signaling of reward prediction or anticipation. It is unclear, however, whether the translation of neural representation of reward value to behavioral drive is affected in schizophrenia. In order to examine how abnormal neural processing of response valuation and initiation affects incentive motivation in schizophreni...